TBW Assessment by Deuterium Dilution in Spanish Adolescents

Congreso para especialistas en Nutrición, Actividad Física y Composición CorporalINTRODUCTION: Total body water (TBW) assessment is a cornerstone in order to validate equations to estimate body composition components as fat mass and fat free mass. Deuterium dilution technique (D2DT) is considered the gold standard method to assess TBW, however in Spain there are not any reference data using D2DT. The knowledge of specific references for Spanish population must be a goal for the biological studies of Spanish people. OBJECTIVE: It was our aim to assess TBW using the D2DT in a sample of Spanish adolescents. METHODS: 224 specimens of urine from 150 adolescents (113 girls and 111 boys) were taken to analyze. A dose of 0.1 grams of 2D2O per Kg of body weight was administrated; afterwards it was followed by 4-hours stabilization period. The isotope (deuterium oxide (D2O)) dilution method was used to measure TBW with an isotope-ratio mass-spectrometer. Averages by sex and Tanner stages were calculated for %TBW and TBW. General lineal model were used to analyze differences and interactions between groups. RESULTS: %TBW was significantly different between boys and girls (58.98_5.59% vs 55.5_4.28%, P0.05). CONCLUSIONS: This study has been the first in Spain, which have measured TBW in vivo using D2DT. These data can be useful to validate new methods and equations from bioimpedance analysis to estimate TBW.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Coca-Col

A New Approach to Express Regional Adiposity and Its Association with Blood Lipids, Inflammation and Insulin Resistance Markers

Regional adiposity is classically related with inflammation, insulin resistance (IR) and an altered blood lipid profile. Traditionally, central adiposity expressed as a ratio (%FM) = fat mass/total mass of the region is the variable most used in research. However, this ratio does not account for total bodily fat mass (TFM). So, a great accumulation in a region, where lean mass is more important than fat, could be more associated with risk factors than other with less absolute fat (kg) but higher percentage (in instance abdomen). PURPOSE: To analyse the associations between the ratio (RW) = regional fat mass (kg) / TFM (kg) and blood lilid profile, IR and inflammation. METHODS: Sixty-two pre-menopausal and healthy women were recruited for this study (age, 39.6 ±7.2 years; BMI, 29.2 ±4.2 kg.m-2; total %TFM, 42.0 ±5.9%). Weight and height were measured to the nearest 0.1 kg and 0.1 cm respectively, and body composition was estimated with dual energy x-ray aborptiometry. RWF were calculated for trunk (RWT), lower limbs (RWLL) and upper limbs (RWUL). Insulin, glycaemia and insulin sensitivity (HOMA) were the IR markers. C-reactive protein (CRP) and Tumour Necrosis Factor (TNF-α) were the inflammation variables. Total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides (TG) were also measured. Partial correlations adjusted to TFM between RW and blood markers were carried out. RESULTS: Significant correlations were found between RWUL and HOMA (r=0.276, P<0.05), TG (r=0.292, P<0.05) and insulin (r=0.271, P<0.05). RWT was also correlated with blood lipids: TG (r=0.278, P<0.05) and LDL (r=-0.318, P<0.05). Finally, RWLL was the ratio with more number of associations: HOMA (r=-0.274, P<0.05), TG (r=-0.342, P<0.01), LDL (r=0.317, P<0.05) and insulin (r=-0.253, P<0.05). Abdominal and trunk %FM were only correlated with HOMA (r=0.380, P<0.01) and LDL (r=0.264, P<0.05) respectively. CONCLUSION: In our sample, regional fat mass contribution (RW) for whole body FM showed more associations with blood markers than classical ratios (regional %FM). These findings highlighted RW ratios were well correlated with inflammatory and IR risk factors, which in turn could be useful to express positive or negative results in future studies. This issue requires further investigation.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Correlates of objectively assessed physical activity and sedentary time in children: a cross-sectional study (The European Youth Heart Study).

BACKGROUND: Identifying leisure time activities performed before and after school that influence time in physical activity (PA) and/or time spent sedentary can provide useful information when designing interventions aimed to promote an active lifestyle in young people. The purpose of this study was to examine associations between mode of transportation to school, outdoor play after school, participation in exercise in clubs, and TV viewing with objectively assessed PA and sedentary behaviour in children. METHODS: A total of 1327 nine- and 15-year-old children from three European countries (Norway, Estonia, Portugal) participated as part of the European Youth Heart Study. PA was measured during two weekdays and two weekend days using the MTI accelerometer, and average percent of time in moderate-to-vigorous PA (MVPA) and time spent sedentary were derived. Potential correlates were assessed by self-report. Independent associations between self-reported correlates with percent time in MVPA and percent time sedentary were analysed by general linear models, adjusted by age, gender, country, measurement period, monitored days and parental socio-economic status. RESULTS: In 9-year-olds, playing outdoors after school was associated with higher percent time in MVPA (P < 0.01), while participation in sport clubs was associated with higher percent time in MVPA (P < 0.01) in 15-year-olds. No associations with percent time sedentary were observed in either age group. CONCLUSION: Frequency of outdoor play after school is a significant correlate for daily time in MVPA in 9-year-olds, while this correlate is attenuated in favour of participation in sport and exercise in clubs in 15-year-olds. Targeting walking to school or reduced TV viewing time in order to increase time in daily MVPA in children is unlikely to be sufficient. Correlates related to time spent sedentary need further examination.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Validity of air-displacement plethysmography in the assessment of body composition changes in a 16-month weight loss program

OBJECTIVE: To compare the accuracy of air displacement plethysmography (ADP) and dual energy x-ray absorptionmetry (DXA) in tracking changes in body composition after a 16 month weight loss intervention in overweight and obese females. METHODS: 93 healthy female subjects (38.9 ± 5.7 yr, 159.8 ± 5.6 cm, 76.7 ± 9.9 kg, 30.0 ± 3.4 kg/m(2)) completed a 16 month weight loss intervention. Eligible subjects attended 15 treatment sessions occurring over the course of 4 months with educational content including topics relating to physical activity and exercise, diet and eating behavior, and behavior modification. In the remaining 12 months, subjects underwent a lifestyle program designed to increase physical activity and improve eating habits. Before and after the intervention, subjects had their percent body fat (%fat), fat mass (FM), and fat-free mass (FFM)) assessed by DXA and ADP. RESULTS: Significant differences (p ≤ 0.001) were found between DXA and ADP at baseline %fat (46.0 % fat vs. 42.0 % fat), FM (35.3 kg vs. 32.5 kg) and FFM (40.8 kg vs. 44.2 kg) as well as at post intervention for %fat (42.1% fat vs. 38.3 % fat), FM (30.9 kg vs. 28.4 kg) and FFM (41.7 kg vs. 44.7 kg). At each time point, ADP %fat and total FM was significantly lower (p ≤ 0.001) than DXA while FFM was significantly higher (p ≤ 0.001). However, both techniques tracked %fat changes similarly considering that there were no differences between the two means. Furthermore, a Bland-Altman analysis was performed and no significant bias was observed, thus demonstrating the ability of ADP to measure body fat across a wide range of fatness. CONCLUSION: At baseline and post weight loss, a significant difference was found between ADP and DXA. However, the results indicate both methods are highly related and track changes in %fat similarly after a weight loss program in overweight and obese females. Additionally, the mean changes in %fat were similar between the two techniques, suggesting that ADP can be translated to its use in clinical practice and research studies as DXA currently is used

Fitness but not weight status is associated with projected physical independence in older adults.

Obesity and fitness have been associated with older adults' physical independence. We aimed to investigate the independent and combined associations of physical fitness and adiposity, assessed by body mass index (BMI) and waist circumference (WC) with the projected ability for physical independence. A total of 3496 non-institutionalized older adults aged 65 and older (1167 male) were included in the analysis. BMI and WC were assessed and categorized according to established criteria. Physical fitness was evaluated with the Senior Fitness Test and individual test results were expressed as Z-scores. Projected ability for physical independence was assessed with the 12-item composite physical function scale. Logistic regression was used to estimate the odds ratio (OR) for being physically dependent. A total of 30.1 % of participants were classified as at risk for losing physical independence at age 90 years. Combined fitness and fatness analysis demonstrated that unfit older adults had increased odds ratio for being physically dependent in all BMI categories (normal: OR = 9.5, 95 %CI = 6.5-13.8; overweight: OR = 6.0, 95 %CI = 4.3-8.3; obese: OR = 6.7, 95 %CI = 4.6-10.0) and all WC categories (normal: OR = 10.4, 95%CI = 6.5-16.8; middle: OR = 6.2, 95 %CI = 4.1-9.3; upper: OR = 7.0, 95 %CI = 4.8-10.0) compared to fit participants that were of normal weight and fit participants with normal WC, respectively. No increased odds ratio was observed for fit participants that had increased BMI or WC. In conclusion, projected physical independence may be enhanced by a normal weight, a normal WC, or an increased physical fitness. Adiposity measures were not associated with physical independence, whereas fitness is independently related to physical independence. Independent of their weight and WC status, unfit older adults are at increased risk for losing physical independence.D.A.S. is supported by a scholarship from the Portuguese Foundation for Science and Technology (SFRH/BPD/92462/2013). L.S. conducted this work during a visiting scholar period to the Faculty of Human Kinetics, University of Lisbon, Portugal, supported by the Capes Foundation within the Ministry of Education, Brazil (Process: 88887.065407/2014-00). UE was partly funded by the MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (Grant MC_UU_12015/3)This is the final version of the article. It first appeared from Springer via https://doi.org/10.1007/s11357-016-9911-

Physical Activity and Pediatric Obesity:A Quantile Regression Analysis

PURPOSE: We aimed to determine if moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) were independently associated with body mass index (BMI) and waist circumference (WC) in children and adolescents. METHODS: Data from the International Children’s Accelerometry Database (ICAD) were used to address our objectives (N=11,115; 6-18y; 51% female). We calculated age and gender specific body mass index (BMI) and waist circumference (WC) Z-scores and used accelerometry to estimate MVPA and total SB. Self-reported television viewing was used as a measure of leisure time SB. Quantile regression was used to analyze the data. RESULTS: MVPA and total SB were associated with lower and higher BMI and WC Z-scores, respectively. These associations were strongest at the higher percentiles of the Z-score distributions. After including MVPA and total SB in the same model the MVPA associations remained, but the SB associations were no longer present. For example, each additional hour per day of MVPA was not associated with BMI Z-score at the 10(th) percentile (b=-0.02, P=0.170), but was associated with lower BMI Z-score at the 50(th) (b=-0.19, P<0.001) and 90(th) percentiles (b=-0.41, P<0.001). More television viewing was associated with higher BMI and WC and the associations were strongest at the higher percentiles of the Z-score distributions, with adjustment for MVPA and total SB. CONCLUSIONS: Our observation of stronger associations at the higher percentiles indicate that increasing MVPA and decreasing television viewing at the population-level could shift the upper tails of the BMI and WC frequency distributions to lower values, thereby lowering the number of children and adolescents classified as obese

Reciprocal effects among changes in weight, body image, and other psychological factors during behavioral obesity treatment: a mediation analysis

<p>Abstract</p> <p>Background</p> <p>Changes in body image and subjective well-being variables (e.g. self-esteem) are often reported as outcomes of obesity treatment. However, they may, in turn, also influence behavioral adherence and success in weight loss. The present study examined associations among obesity treatment-related variables, i.e., change in weight, quality of life, body image, and subjective well-being, exploring their role as both mediators and outcomes, during a behavioral obesity treatment.</p> <p>Methods</p> <p>Participants (BMI = 31.1 ± 4.1 kg/m²; age = 38.4 ± 6.7 y) were 144 women who attended a 12-month obesity treatment program and a comparison group (n = 49), who received a general health education program. The intervention included regular group meetings promoting lasting behavior changes in physical activity and dietary intake. Body image, quality of life, subjective well-being, and body weight were measured at baseline and treatment's end. Mediation was tested by multiple regression and a resampling approach to measure indirect effects. Treatment group assignment was the independent variable while changes in weight and in psychosocial variables were analyzed alternatively as mediators and as dependent variables.</p> <p>Results</p> <p>At 12 months, the intervention group had greater weight loss (-5.6 ± 6.8% vs. -1.2 ± 4.6%, p < .001) and larger decreases in body size dissatisfaction (effect size of 1.08 vs. .41, p < .001) than the comparison group. Significant improvements were observed in both groups for all other psychosocial variables (effect sizes ranging from .31–.75, p < .05). Mediation analysis showed that changes in body image and body weight were concurrently mediators and outcomes of treatment, suggesting reciprocal influences. Weight loss partially mediated the effect of treatment on quality of life and on self-esteem but the reciprocal effect was not observed.</p> <p>Conclusion</p> <p>Changes in weight and body image may reciprocally affect each other during the course of behavioral obesity treatment. No evidence of reciprocal relationships was found for the other models under analysis; however, weight changes partially explained the effects of treatment on quality of life and self-esteem. Weight and psychosocial changes co-occur during treatment and will probably influence each other dynamically, in ways not yet adequately understood. Results from this study support the inclusion of intervention contents aimed at improving body image in weight management programs.</p

Correction to: A closer look at the relationship among accelerometer-based physical activity metrics: ICAD pooled data.

Following publication of the original article [1], the author reported that the name of the collaborator group was missing from the author group